三、主要研究成果
(一) 主持科研项目
1.主持国家自然科学基金青年项目《LncRNA HOXA11-AS/miR-214 调控骨形成-骨血管生成偶联在运动防治骨质疏松中的机制研究》,20.5万,2019年;
2.主持中国博士后科学基金特别资助项目《HOXA11-AS/miR-214 在运动防治骨质疏松中的机制研究》,15万, 2019 年;
3.主持广东省自然科学基金面上项目《运动介导骨骼肌外泌体LIFR防治骨质疏松症的作用机制研究》,10万,2022年;
4.主持中国博士后科学基金面上一等资助项目《运动调控 LncRNA HOXA11-AS 促进骨血管生成的作用 研究》,8万,2018 年;
5. 广东省哲学社会科学规划 2023 年度青年项目《主动健康背景下体医融合防治骨质疏松症的模式构建》,批准号: GD23YTY04,2.0 万元 ,2023;
6.主持广州市自然科学基金,《miR-181a/FOXO在运动防治骨质疏松中的机制研究》,5万,2022年;
7.主持广东省高校特色创新类项目《运动介导miR-181a/FOXO信号通路改善骨代谢的作用机制研究》 ,10万,2021年
8. 主持广州体育学院青年博士资助类科研项目《运动调控HIF1α促进骨形成及骨血管生成的作用机制研究》,2021年
9. 主持广州体育学院师资队伍建设类高层次人才培育项目《LncRNA HOXA11-AS在运动抵抗骨丢失中的作用机制研究》,2021年
10. 主持华南师范大学青年教师培优项目,3万,2019年
11. 主持上海体育学院研究生教育创新计划(博士生),2万,2016 年,
12. 参与 2017年国家自然科学基金青年项目,81702235,经费:20万;
13. 参与 2015年国家自然科学基金面上项目,81572242,经费:68.4万。
(二) 公开发表SCI及中文核心期刊收录论文
Yuan Y#, Chen K, # Chen X, et al. Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways. Front Pharmacol, 2020. 11: 238.(SCI)
Yuan Y, Guo J, Zhang L, et al. MiR-214 Attenuates the Osteogenic Effects of Mechanical Loading on Osteoblasts. Int J Sports Med. 2019. 40(14):931-940.(SCI)
Yuan Y, Zhang L, Tong X, et al. Mechanical Stress Regulates Bone Metabolism through MicroRNAs. J Cell Physiol, 2017. 232(6): 1239-1245.(SCI)
Yuan Y, Chen X, Zhang L, et al. The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis. Prog Biophys Mol Biol, 2016. 122(2): 122-130.(SCI)
Huang, Jiawen; Xu, Yang; Wang, Yuxuan; Su, Zhiang; Li, Tingting; Wu, Sisi; Mao, Yuheng; Zhang, Shihua; Weng, Xiquan*; Yuan, Yu*, Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases, Pharmaceutics, 2023, 15(1).(通讯作者, SCI)
Chen K#, Yuan Y#, Wang Z, et al. Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation. J Cell Physiol, 2018. 234(5): 6477-6488.(共同第一, SCI)
Sun Y#, Yuan Y#, Wu W, et al. The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation [J]. Cell Biosci, 2021, 11(1): 88.(共同第一, SCI)
Tingting LI, Shihua ZHANG, Yuxuan YANG, Lingli ZHANG, Yu YUAN*,Jun ZOU*.The co-regulation of circadian clock genes and microRNAs in bone metabolism [J]. Journal of Zhejiang University SCIENCE B,2022. (通讯作者, SCI)
Li, Tingting, Liang Chen, Yu Yuan*, Rengfei Shi*. 2023. The Current Status, Prospects, and Challenges of Shape Memory Polymers Application in Bone Tissue Engineering [J]. Polymers,2023.15(3): 556(通讯作者, SCI)
Zhang S#, Li T#, Feng Y, Zhang K, Zou J, Weng X, Yuan Y*, Zhang L*. Exercise improves subchondral bone microenvironment through regulating bone-cartilage crosstalk. Frontiers in endocrinology, 2023, 14: 1159393.
元宇,饶林振,张士花,徐洋,李婷婷,邹军,翁锡全.运动介导microRNAs调控骨代谢的研究进展[J/OL].生理学报:1-18[2023-01-02]. (CSCD 核心,北大核心)
元宇, 张玲莉, 长链非编码RNA介导Wnt/β-catenin信号通路调控骨代谢的研究进展[J].生物工程学报,2021,(07): 1-9. (卓越期刊计划,CSCD 核心,北大核心)
元宇,徐洋,翁锡全.成纤维生长因子2介导骨代谢相关信号通路对骨形成的调控[J].中华骨质疏松和骨矿盐疾病杂志,2022,15(01):82-88. (CSCD 核心,北大核心)
元宇,仝晓阳,邹军*. miR-214 对骨形成的抑制作用[J]. 中国生物化学与分子生物学报,2017,(02):133-137.(CSCD 核心,北大核心)
元宇,郭健民,张玲莉,仝晓阳,陈熙,邹军*. 机械应力对骨组织细胞影响的研究进展[J]. 中国老年学杂志,2016,(03):725-728. (北大核心)
元宇,郭健民,邹军*. OPG/RANKL/RANK 信号通路在运动与骨免疫学中的研究进展[J]. 中国骨质疏松杂志,2015,(08):1005-1010. (CSCD 核心,北大核心)
徐洋,饶林振,黄嘉雯,翁锡全*,元宇*.运动介导骨钙素调控脂肪代谢的研究进展[J/OL].中国骨质疏松杂志:1-11[2022-05-22]. (通讯作者,CSCD 核心,北大核心)
蔺海旗, 陈亮, 王震, 林文弢*, 元宇*, 运动对线粒体介导骨骼肌细胞凋亡信号通路的影响[J].中国细胞生物学学报, 2021, (43): 118-124. (共同通讯作者,CSCD 核心)
郭梁,任占兵,谭先明,元宇*. 绝经后妇女生活方式与骨健康的关系[J].中国老年学杂志, 2019, 39(21):5373-5375.(通讯作者,北大核心)
李婷婷,张士花,杨雨轩,元宇*,邹军*.生物钟基因调控骨代谢的研究进展[J].生命科学,2021,33(08):1028-1036. (通讯作者,CSCD 核心,北大核心)
杨雨轩,李婷婷,张士花,元宇*,邹军*.LncRNA 介导Runx2调控骨疾病的研究进展,生命 科学,2022,34(01):55-61. (通讯作者,CSCD 核心,北大核心)
Chen K#, Qiu P#, Yuan Y, Zheng L, He J, Wang C, Guo Q, Kenny J, Liu Q, Zhao J, Chen J, Tickner J, Fan S, Lin X*, Xu J*. Pseurotin A inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species. Theranostics, 2019, 9(6):1634-1650.(SCI,高被引论文,影响因子:11.5)
Liu L, Yuan Y, Zhang S, Xu J, Zou J. Osteoimmunological insights into the pathogenesis of ankylosing spondylitis. Journal of cellular physiology, 2021.(Online ahead of print) (SCI)
Chen X, Guo J, Yuan Y, Sun Z, Chen B, Tong X, Zhang L, Shen C, Zou J*. Cyclic compression stimulates osteoblast differentiation via activation of the Wnt/beta-catenin signaling pathway. Molecular medicine reports, 2017, 15(5): 2890-2896. (SCI)
Zhang L#, Chen X#, Wu J, Yuan Y, Guo J, Biswas S, Li B, Zou J*. The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength. Journal of bone and mineral metabolism, 2017, 35(3): 265-277. (SCI)
Zhou X, Cao H, Yuan Y, et al. Biochemical Signals Mediate the Crosstalk between Cartilage and Bone in Osteoarthritis. BioMed Research International.2020. https://doi.org/10.1155/2020/5720360(SCI)
Sun Y#, Kuek V#, Liu Y, Tickner J, Yuan Y, et al. MiR-214 is an important regulator of the musculoskeletal metabolism and disease. Journal of cellular physiology. 2018, 234(1): 231-245.(SCI)
Wang L, Chen K, He J, Kenny J, Yuan Y, Chen J, Liu Q, Tan R, Zhao J, Xu J. Cytochalasin Z11 inhibits RANKL-induced osteoclastogenesis via suppressing NFATc1 activation. RSC Advances, 2019, 9(66): 38438-38446.(SCI)
Zhang L, Yuan Y, Wu W, et al. Medium-Intensity Treadmill Exercise Exerts Beneficial Effects on Bone Modeling Through Bone Marrow Mesenchymal Stromal Cells. Frontiers in cell and developmental biology, 2020, 8: 600639.(SCI)
Chen X, Wang C, Qiu H, Yuan Y, Chen K, Cao Z, Xiang Tan R, Tickner J, Xu J, Zou J. Asperpyrone A attenuates RANKL‐induced osteoclast formation through inhibiting NFATc1, Ca2+ signalling and oxidative stress. Journal of Cellular and Molecular Medicine 2019; 23(12): 8269-8279.(SCI)
Guo J, Yuan Y, Zhang L, Wang M, Tong X, Liu L, Zhang M, Li H, Chen X, Zou J. Effects of exercise on the expression of long non-coding RNAs in the bone of mice with osteoporosis. Exp Ther Med 2022; 23(1): 70.(SCI)
Chen X, Qiu H, Wang C, Yuan Y, Tickner J, Xu J, Zou J. Molecular structure and differential function of choline kinases CHKα and CHKβ in musculoskeletal system and cancer. Cytokine & Growth Factor Reviews 2017; 33: 65-72.(SCI)
Chen X, Li L, Guo J, Zhang L, Yuan Y, Chen B, Sun Z, Xu J, Zou J. Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice. Oncotarget 2016; 7(44): 71072-71086.(SCI)
Wang L, Chen K, He J, Kenny J, Yuan Y, Chen J, Liu Q, Tan R, Zhao J, Xu J. Cytochalasin Z11 inhibits RANKL-induced osteoclastogenesis via suppressing NFATc1 activation. RSC Advances 2019; 9(66): 38438-38446(SCI)
Wang D, Cao H, Hua W, Gao L, Yuan Y, Zhou X, Zeng Z. Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair. Membranes (Basel) 2022; 12(7).(SCI)
Huang Mei; Xu Shaozhe; Liu Lifei; Zhang Miao; Guo Jianmin; Yuan Yu; Xu Jiake; Chen Xi; Zou Jun, m6A Methylation Regulates Osteoblastic Differentiation and Bone Remodeling, Frontiers in Cell and Developmental Biology, 2021, 9.(SCI)
Weng Xiquan; Lin Jieru; Yuan Yu; Lin Baoxuan; Huang Weiwei; Tin Hiu Tung; Li Jia; Yan Xu; Lin Wentao; Chen Hao, Intermittent Hypoxia Exposure Helps to Restore the Reduced Hemoglobin Concentration During Intense Exercise Training in Trained Swimmers, Frontiers in Physiology, 2021, 12.(SCI)
四、社会兼职
1. 中国老年学和老年医学学会运动健康科学分会青年委员会委员;
2. 中国康复医学会体育保健分会青年工作组委员;
3.《Frontiers Pharmacology 》、《cells 》、《中国组织工程研究》、《中国细胞生物学报》等杂志审稿专家;
4. 《中国组织工程研究》杂志社医工融合联盟第一届委员;
5. 国家自然科学基金通讯评审专家、广东省基金项目评审专家。